Overview

A glycinated derivative of azelaic acid, it performs three primary functions essential for skin health: limiting sebum production, acting as an anti-inflammatory agent, and inhibiting melanin synthesis. Azelaic acid, the core component, is proven effective in treating rosacea, acne, and melasma. Considered a safer alternative to hydroquinone, azelaic acid achieves these results without adverse side effects, making it a preferred alternative for long-term skincare usage. The underlying mechanism of azelaic acid's effectiveness lies in its role as a PPAR-gamma activator. This action builds resilience against the inflammatory responses that trigger both acne and hyperpigmentation.

Skin benefits

Normalizes sebum production Skin brightening Skin hydrating Improves skin elasticity

What research has shown

Azelaic acid is a natural plant-sourced saturated dicarboxylic acid which has demonstrated efficacy as monotherapy or in combination in the treatment of rosacea, acne vulgaris (both inflammatory and comedonal) and several disorders of hyperpigmentation including melasma and post-inflammatory hyperpigmentation. azelaic acid has shown to be particularly effective in the treatment of Rosacea due to its inhibition of KLK5 and through activation of PPARγ. It is this PPARγ activation that also lends azelaic acid to be effetive in the treatment of melanin issues, as PPARs are expressed in human melanocytes and PPAR⍺ and PPARγ activators inhibit melanocyte growth and stimulate melanogenesis.

Peer reviewed science

• Journal of Dermatological Treatment (2022)
• Journal of Cosmetic Dermatology (2023)
• Experimental dermatology (2010)