Overview

Derived from chamomile, Bisabolol stands out for its exceptional anti-inflammatory and wound-healing capabilities. It targets core skin irritant molecules including IL1-alpha, IL-6, IL8, and TNF-alpha. Moreover, Bisabolol enhances skin penetration remarkably, making it highly effective in delivering therapeutic benefits deep within the skin. Bisabolol also plays a role in suppressing AGE-induced inflammatory reactions and preventing extracellular matrix degeneration by blocking NF-kappaB, p38, and JNK signaling pathways.

Skin benefits

Anti-inflammatory properties can help reduce redness Wound healing capability can help with eczema and reducing skin surface of wounds

What research has shown

Alpha-bisabolol (α-bisabolol), an unsaturated monocyclic sesquiterpene alcohol, is known as one of the most-used herbal constituents. Its antioxidant properties are primarily linked to reducing reactive oxygen and nitrogen species (ROS/RNS), malondialdehyde (MDA), and glutathione (GSH) depletion, while enhancing myeloperoxidase (MPO) activity, superoxide dismutase (SOD), and catalase (CAT) levels. α-Bisabolol also demonstrates anti-apoptotic capabilities through the upregulation of bcl-2 expression and the downregulation of bax, P53, APAF-1, caspase-3, and caspase-9. Its anti-inflammatory actions are evident in the decreased levels of TNF-α, IL-1β, IL-6, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2), along with inhibited activation of ERK1/2, JNK, NF-κB, and p38 pathways. The compound's antimicrobial benefits stem from its ability to decrease the viability of infected cells, alongside enhancing cognitive functions by lowering levels of bax, cleaved caspases-3 and 9, β-secretase, and cholinesterase activities and increasing bcl-2 levels.

Peer reviewed science

• Life Sciences (2022)
• Nutrients (2022)
• International immunopharmacology (2020)